MICROSOFT 365 SECURITY
Protect your people and data across email, collaboration, and AI while simplifying security and compliance.
Beyond Native Protection
Microsoft 365 provides built-in security and compliance, but risk extends across the people, accounts, data, AI, and communications connected to it. The most effective Microsoft 365 security solutions extend visibility and control across these risk areas to stop advanced threats, prevent data loss, and govern communications.
Detect and stop phishing, BEC, account compromise, and multichannel threats across Microsoft 365.
Control how people access, share, and use sensitive data across Microsoft 365, including Copilot and AI.
Connect threat protection, data controls, and communications governance to improve visibility and operations.
Advanced Email Security
Strengthen Microsoft 365 email security to stop advanced attacks before they lead to account compromise, fraud, or business disruption. Proofpoint Core Email Protection (part of Collaboration Security Prime) detects evasive threats with multilayered analysis and global threat intelligence, helping security teams investigate and respond faster.
Advanced Threat Detection
Detect phishing, BEC, malicious URLs, QR codes, and malware designed to evade email defenses.
API or Gateway-Based Deployment
Augment Microsoft 365 via API integration or Secure Email Gateway for greater control over mail flow.
Automated Detection and Response
Find and remediate malicious messages after delivery and streamline investigation with integrated workflows.
Multi-Channel Protection
Contain threats that move beyond email and exploit trusted accounts, suppliers, and collaboration channels. Collaboration Security Prime connects threat and identity signals across Microsoft 365 and beyond to help security teams uncover attacks that span users, accounts, and applications.
Account Takeover Protection
Detect compromised accounts based on behavioral signals, login anomalies, and threat intelligence.
Cross-Channel Threat Visibility
Correlate attack activity across email, collaboration, and cloud apps for faster investigation and response.
Supplier Threat Protection
Identify threats from compromised supplier accounts and reduce risk across trusted business relationships.
Unified Data Security
Protect sensitive data from accidental exposure, insider risk, and unsafe AI use without disrupting legitimate work. Proofpoint Data Security connects data activity with user context across Microsoft 365, Copilot, and other AI tools so teams can identify risky behavior and apply the right controls before data is exposed or lost.
DLP for Microsoft 365
Apply consistent policies to prevent accidental or intentional data loss across email, cloud apps, and endpoints.
Copilot and AI Data Security
Monitor prompts, uploads, and responses to prevent sensitive data exposure across Copilot and other AI tools.
Data Access Governance
Find excessive permissions and risky access before people or AI agents expose sensitive data.
Centralized Governance
Keep Microsoft 365 communications ready for compliance reviews, investigations, and legal requests. Proofpoint Digital Communications Governance extends governance beyond Microsoft 365 so teams can manage communications and records consistently across required channels.
Capture and Archiving
Capture and retain email, Teams, and other communications with context and conversation history intact.
Supervision and Review
Monitor communications for policy risks and focus reviewers on higher-risk content with intelligent workflows.
eDiscovery and Investigations
Search, analyze and produce communications faster for legal hold, investigations, audits, and eDiscovery.
Why Proofpoint
| Capabilities | Native Microsoft 365 Protections | Proofpoint |
|---|---|---|
| Advanced email threats | Includes built-in anti-phishing, Safe Links, Safe Attachments, and post-delivery response | Stops phishing, BEC, malware, and evasive threats with multilayered pre- and post-delivery detection |
| Deployment flexibility | Delivers protection through Microsoft's native email security architecture | Supports deployment via Graph API or Secure Email Gateway to fit your mail architecture |
| Cross-channel attacks | Correlates threat signals across Microsoft Defender and Microsoft 365 workloads | Correlates threats across email, collaboration, cloud apps, and identity to expose cross-channel attacks |
| AI data security | Protects AI interactions through Purview, Defender, Entra, and other Microsoft security controls | Unifies data visibility, user risk, and DLP controls to protect sensitive data across sanctioned and shadow AI |
| Communications governance | Provides retention, eDiscovery, and communications compliance across Microsoft 365 and supported third-party sources | Enables capture, retention, supervision, search, and investigation across 80+ channels |
Customer Stories
"Our first line of defense for global email and communications. All inbound and outbound mail to and from Microsoft 365 is routed through Proofpoint."
Paul Dumbleton
CISSP and Manager, Infrastructure Security Engineer, Perrigo
"Proofpoint was easy to configure and easy to integrate into our Microsoft 365 platform ... users don’t even have to think about it."
Norman McKeown
Assoc. Director of IT, MHA
"Proofpoint ... takes seconds to get my search results, which is a huge improvement over what I was experiencing using Microsoft tools."
David McBride
Dir., Support Services, Mississippi Dept. of Child Protection Services
Resources
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Recommended for You
Microsoft 365 includes native security controls, but some organizations need additional protection based on their risk, architecture, and security requirements. Additional security can strengthen advanced threat detection, provide flexible email deployment options, extend visibility across collaboration channels, and connect risk across people, accounts, data, and AI.
Look for Microsoft 365 email security that detects advanced phishing, BEC, malware, malicious URLs, QR codes, and other evasive threats. Evaluate pre- and post-delivery protection, automated remediation, threat intelligence, investigation workflows, and deployment flexibility. The right solution should strengthen protection while reducing investigation and response effort.
Start by understanding what sensitive data people and Copilot can access. Apply data loss prevention and access controls to reduce excessive access and prevent sensitive data exposure. Organizations should also monitor AI interactions, including prompts, uploads, and responses, and extend protection to sanctioned and shadow AI tools beyond Copilot.
A Microsoft 365 compliance solution should help teams capture, retain, supervise, search, and investigate business communications. Look for support across email, Teams, and other required channels, with capabilities for retention, supervision, legal hold, eDiscovery, investigations, and record reconciliation. Broader channel coverage can help organizations manage communications consistently as work expands beyond Microsoft 365.
Security teams need visibility into threats as they move between email, accounts, collaboration tools, cloud apps, and trusted relationships. Cross-channel protection should correlate threat and identity signals, detect compromised accounts, and support coordinated investigation and response. This helps teams follow an attack across connected environments instead of investigating each channel in isolation.
Proofpoint adds layered security and compliance controls around Microsoft 365 across email, collaboration, data, AI, and digital communications. Organizations can augment Microsoft 365 email security through Graph API integration or a Secure Email Gateway, then extend protection with account compromise detection, data security, AI controls, and communications governance.
